Compile Data Set for Download or QSAR
Report error Found 306 Enz. Inhib. hit(s) with Target = 'Acid ceramidase'
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367209BDBM367209(2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367209BDBM367209(2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50: 0.800nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238556BDBM50238556(CHEMBL4093029)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238557BDBM50238557(CHEMBL4103207)
Affinity DataIC50: 1nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367226BDBM367226(4-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50: 1nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238562BDBM50238562(CHEMBL4084295)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238574BDBM50238574(CHEMBL4092051)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238573BDBM50238573(CHEMBL4062592)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238572BDBM50238572(CHEMBL4065362)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238569BDBM50238569(CHEMBL4075447)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238568BDBM50238568(CHEMBL4100744)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511300BDBM50511300(CHEMBL4580541)
Affinity DataIC50: 3nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367195BDBM367195(6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367194BDBM367194(5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367195BDBM367195(6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50: 3nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367194BDBM367194(5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50: 3nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431244BDBM50431244(CHEMBL2333064)
Affinity DataIC50: 4nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238578BDBM50238578(CHEMBL4071239)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238558BDBM50238558(CHEMBL4075028)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556798BDBM50556798(CHEMBL4742096)
Affinity DataIC50: 5nMAssay Description:Inhibition of human acid ceramidase using N-lauroyl ceramide incubated for 1 hr by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511282BDBM50511282(CHEMBL4592427)
Affinity DataIC50: 6nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238563BDBM50238563(Benzoimidazole-1-Carboxylic Acid Hexylamide | CHEM...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431255BDBM50431255(CHEMBL2333053)
Affinity DataIC50: 7nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431246BDBM50431246(CHEMBL2333062 | US9428465, 32)
Affinity DataIC50: 7nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431246BDBM50431246(CHEMBL2333062 | US9428465, 32)
Affinity DataIC50: 7nMpH: 4.5Assay Description:r-AC protein samples were pre-incubated with various concentrations of test compounds or vehicle control in 100 mM NaH2PO4/citrate buffer pH 4.5, 0.1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238577BDBM50238577(CHEMBL4096883)
Affinity DataIC50: 7nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238570BDBM50238570(CHEMBL4089655)
Affinity DataIC50: 7nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431253BDBM50431253(CHEMBL2333055)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238576BDBM50238576(CHEMBL4076230)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238561BDBM50238561(CHEMBL4101140)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367187BDBM367187(5-chloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50: 9nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 319796BDBM319796(US10174015, Compound 9)
Affinity DataIC50: 9nMAssay Description:Inhibition of rat acid ceramidase expressed in HEK293 cells using N-lauroylceramide as substrate after 30 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238565BDBM50238565(CHEMBL4095461)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431271BDBM50431271(CHEMBL2333033 | US9428465, 4)
Affinity DataIC50: 10nMpH: 4.5Assay Description:r-AC protein samples were pre-incubated with various concentrations of test compounds or vehicle control in 100 mM NaH2PO4/citrate buffer pH 4.5, 0.1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367186BDBM367186(6-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50: 10nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367198BDBM367198(5-cyano-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50: 11nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367196BDBM367196(2-oxo-N-(4-phenylbutyl)-5- (trifluoromethyl)-1,3- ...)
Affinity DataIC50: 11nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431271BDBM50431271(CHEMBL2333033 | US9428465, 4)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431271BDBM50431271(CHEMBL2333033 | US9428465, 4)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat acid ceramidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367185BDBM367185(5-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431254BDBM50431254(CHEMBL2333054)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556790BDBM50556790(CHEMBL4777626)
Affinity DataIC50: 13nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAcid ceramidase(Rat)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50431260BDBM50431260(CHEMBL2333048)
Affinity DataIC50: 13nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556791BDBM50556791(CHEMBL4754069)
Affinity DataIC50: 14nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 241946BDBM241946(US9428465, 24)
Affinity DataIC50: 14nMpH: 4.5Assay Description:A hAC protein preparation (10 μg) was preincubated with inhibitors (final DMSO concentration 1%) in assay buffer (100 mM sodium phosphate, 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238554BDBM50238554(CHEMBL4094489)
Affinity DataIC50: 14nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367214BDBM367214(6-(4-chlorobenzoyl)-2-oxo-N- (4-phenylbutyl)-1,3- ...)
Affinity DataIC50: 14nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367214BDBM367214(6-(4-chlorobenzoyl)-2-oxo-N- (4-phenylbutyl)-1,3- ...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238566BDBM50238566(CHEMBL4075846)
Affinity DataIC50: 15nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 367187BDBM367187(5-chloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
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