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Compounds Sorted by Binding Targets per Compound

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Compounds Sorted Alphabetically
Compound Name (alphabetical)
Binding Targets
Enz. Inhib. Data
ITC Data
Alternate Compound Names
  • Alpha trans-inducing protein (VP16)
  • COUP transcription factor 2 isoform a
  • Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
  • Disintegrin and metalloproteinase domain-containing protein 17
4 IC50
  • 2-hydroxy-3-[(E)-3-(4-nitrophenyl)-1-oxoprop-2-enyl]-1-cyclohepta-2,4,6-trienone
  • 2-hydroxy-3-[(E)-3-(4-nitrophenyl)acryloyl]cyclohepta-2,4,6-trien-1-one
  • 2-hydroxy-3-[(E)-3-(4-nitrophenyl)prop-2-enoyl]cyclohepta-2,4,6-trien-1-one
  • 3-[(E)-3-(4-nitrophenyl)prop-2-enoyl]-2-oxidanyl-cyclohepta-2,4,6-trien-1-one
  • MLS002701851
  • SMR001565443
  • cid_6302331
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase SYK
2 IC50 18 Kd
  • US10533001, Example Table 9a.1
  • US8501944, 370
  • US8501944, 374
  • US9868729, Example 38
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase SYK
14 IC50 18 Kd
  • US10533001, Example 99
  • US8501944, 372
  • US8501944, 375
  • US9868729, Example 99
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase SYK
2 IC50 18 Kd
  • US10533001, Example Table 9a.4
  • US8501944, 373
  • US8501944, 376
  • US9868729, Example 254
  • EBifunctional epoxide hydrolase 2
  • Epoxide hydrolase
  • Epoxide hydrolase 1
  • Soluble Epoxide Hydrolase
1 Ki 6 IC50
  • US10383835, Compound 1153
  • US8501783, 1153
  • Beta-secretase 1
  • Beta-secretase 2
  • Cathepsin D
  • HIV-1 Protease
4 IC50
  • lysine sulfonamide analogue 9
  • methyl N-[(1S)-1-{[(5R)-5-[(4-aminobenzene)(2-methylpropyl)sulfonamido]-6-hydroxyhexyl]carbamoyl}-2-phenylethyl]-N-methylcarbamate
  • sulfonamide tricyclic analogue, 9
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
3 Ki 22 IC50
1 ΔG°
  • (4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(3S)-3-acetamido-3-formamidopropanoic acid]butanoic acid
  • Ac-DEVD-CHO
  • CHEMBL417149
  • JAK1 (aa 850-1154)
  • JAK2 (aa 808-1132)
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
4 IC50
  • US10206907, Compound 207
  • US8563545, 10
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 8
4 IC50
  • JNK3 inhibitor 5
  • US8562945, 241
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 8
4 IC50
  • JNK3 inhibitor 6
  • US8562945, 242
  • Carbonic anhydrase 2
  • Carbonic anhydrase 9
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 8
4 IC50
  • JNK3 inhibitor 7
  • US8562945, 243
  • Aldo-keto reductase family member 1B10 (AKR1B10)
  • Aldose reductase
  • Aldose reductase (AR)
  • Methylated AKR1B10 K125R/V301L (AKME2MU)
6 IC50
  • MK181
  • Death-associated protein kinase 1
  • Serine/threonine-protein kinase pim-1
  • Serine/threonine-protein kinase pim-2
  • Serine/threonine-protein kinase pim-3
6 Kd
  • HS43
  • HIV-1 protease
  • HIV-1 protease M2
  • HIV-1 protease M3
  • HIV-1 protease M4
4 Ki
  • MIT-2-AD-93 (AD-93)
  • HIV-1 protease M1
  • HIV-1 protease M2
  • HIV-1 protease M3
  • HIV-1 protease M4
4 Ki
  • 3-Hydroxy-N-[(1S,2R)-2-hydroxy-3-[[[5-(5-isoxazolyl)-2-thienyl]sulfonyl](2- methylbutyl)amino]-1-(phenylmethyl)propyl]-benzamide (AF-80)
  • Acetylcholinesterase
  • Carboxylic ester hydrolase
  • Neutrophil cytosol factor 1
  • Pteridine reductase 1
1 Ki 3 IC50 1 Kd
  • 2-methylquinolin-4-amine
  • 4-Aminoquinaldine 4
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
4 Ki 2 IC50
  • US8569311, A-9
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
12 Ki 4 IC50
  • US8569311, E-5
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
13 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-methoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • BROMOMETHOXYPHENYL INHIBITOR
  • valine aspartyl ketone 29
  • valine aspartyl ketone 6
  • valine aspartyl ketone analog 10
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo-2-methoxyphenyl)propanamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 7
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo-2-methoxyphenyl)pentanamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 8
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo-2-methoxyphenyl)-3-phenylpropanamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 9
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo-2-methoxyphenyl)-3-methylbutanamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 10
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-{[1-(5-bromo-2-methoxyphenyl)cyclopropyl]formamido}-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 11
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo-2-methoxyphenyl)pent-4-enamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 12
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo-2-methoxyphenyl)pent-4-ynamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 13
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2R)-2-(5-bromo-2-methoxyphenyl)pent-4-ynamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 14
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
8 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-3-methyl-2-(1-phenylacetamido)butanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 15
  • valine aspartyl ketone analog 9
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2R)-2-hydroxy-2-phenylacetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 16
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-hydroxy-2-phenylacetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 17
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2R)-2-hydroxy-3-methylbutanamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 18
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-hydroxy-3-methylbutanamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 19
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-methoxy-2-phenylacetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 20
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-(2-hydroxy-2-phenylpropanamido)-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 21
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-(2-hydroxy-2,2-diphenylacetamido)-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 22
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-(2-ethyl-2-hydroxybutanamido)-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 23
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-(2-hydroxy-2-methylpropanamido)-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 24
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(1-hydroxycyclopropyl)formamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 25
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-3-methyl-2-[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propanamido]butanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 26
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
8 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(2,5-dimethoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 27
  • valine aspartyl ketone analog 1
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(2,5-dimethoxyphenyl)-2-hydroxyacetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 28
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-bromo-2-methoxyphenyl)-2-hydroxyacetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 30
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
8 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-acetyl-2-methoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 31
  • valine aspartyl ketone analog 15
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-acetyl-2-methoxyphenyl)-2-hydroxyacetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 32
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-{1-[2-methoxy-5-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]acetamido}-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 33
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-{2-hydroxy-2-[2-methoxy-5-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]acetamido}-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 34
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-hydroxy-2-(5-iodo-2-methoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone 35
  • CDK2/CycE
  • Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Voltage-gated calcium channel subunit alpha Cav2.2
3 IC50 1 EC50
  • 3-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}propan-1-ol
  • 3-{[6-(benzylamino)-9-isopropyl-9H-purin-2-yl]amino}propan-1-ol
  • 6-(benzylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurine
  • CHEMBL83980
  • purine deriv. 1
  • CDK2/CycE
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-dependent kinase 1
  • Voltage-gated calcium channel subunit alpha Cav2.2
3 IC50 1 EC50
  • 2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}ethan-1-ol
  • 2-{[6-(benzylamino)-9-isopropyl-9H-purin-2-yl]amino}ethanol
  • 6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-isopropylpurine
  • CHEMBL86066
  • purine deriv. 4
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 2
  • Histone deacetylase 3
4 IC50
  • ZYJ-34v (Compound 2)
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
5 IC50
  • (3S)-3-[(2S)-2-[(4S)-4-[(3S)-3-acetamido-3-formamidopropanoic acid]-4-formamidobutanoic acid]-3-methylbutanamido]-4-oxo-7-phenylheptanoic acid
  • CHEMBL443565
  • Compound 2
  • PHENYL-PROPYL-KETONE INHIBITOR
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
5 IC50
  • (3S)-5-[(2-CHLORO-6-FLUOROBENZYL)SULFANYL]-3-{[N-({2-ETHOXY-5-[(1E)-3-METHOXY-3-OXOPROP-1-ENYL]PHENYL}ACETYL)-D-VALYL]AMINO}-4-OXOPENTANOIC ACID
  • (3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-3-[(2S)-2-(1-{2-ethoxy-5-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}acetamido)-3-methylbutanamido]-4-oxopentanoic acid
  • CINNAMIC ACID METHYL ESTER INHIBITOR
  • Compound 3
  • valine aspartyl ketone analog 14
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(3,5-dibromophenyl)formamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone analog 2
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(5-fluoro-1H-indol-2-yl)formamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone analog 3
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-3-[(2S)-2-[1-(2,5-dimethoxyphenyl)acetamido]-3-methylbutanamido]-5-[(2-methylpropyl)sulfanyl]-4-oxopentanoic acid
  • valine aspartyl ketone analog 4
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-3-[(2S)-2-[1-(2,5-dimethoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone analog 5
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-[(cyclohexylmethyl)sulfanyl]-3-[(2S)-2-[1-(2,5-dimethoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone analog 6
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(2-methoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone analog 7
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(3-methoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone analog 8
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-3-[(2S)-2-{1-[2-ethoxy-5-(2-methoxy-2-oxoethoxy)phenyl]acetamido}-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone analog 11
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
4 IC50
  • US8586620, 56
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
7 IC50
  • CHEMBL1957353
  • US8586620, 43
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-3-[(2S)-2-(1-{2-ethoxy-5-[2-oxo-2-(propan-2-yloxy)ethoxy]phenyl}acetamido)-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone analog 12
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
7 IC50
  • CHEMBL1957354
  • US8586620, 47
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
7 IC50
  • CHEMBL1957352
  • US8586620, 51
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
4 IC50
  • US8586620, 15
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-3-[(2S)-2-{1-[5-(carboxymethoxy)-2-ethoxyphenyl]acetamido}-3-methylbutanamido]-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-4-oxopentanoic acid
  • valine aspartyl ketone analog 13
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Serotonin 1B/1D receptor
4 IC50
  • US8586620, 97
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Serotonin 1B/1D receptor
4 IC50
  • US8586620, 105
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Serotonin 1B/1D receptor
4 IC50
  • US8586620, 110
  • 5-hydroxytryptamine 1D receptor (5HT1D)
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Serotonin 1B/1D receptor
4 IC50
  • US8586620, 111
  • Nitric oxide synthase, brain
  • Nitric oxide synthase, endothelial
  • Nitric oxide synthase, inducible
  • Sodium-dependent noradrenaline transporter
12 IC50
  • CHEMBL2036264
  • US8586620, 114
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-3-[(2S)-2-[1-(5-methanesulfonyl-2-methoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid
  • valine aspartyl ketone analog 16
  • Caspase-1
  • Caspase-3
  • Caspase-7
  • Caspase-8
4 IC50
  • (3S)-3-[(2S)-2-[(2S)-2-[(3S)-3-formamido-3-(phenylformamido)propanoic acid]propanamido]-3-methylbutanamido]-4-oxo-7-phenylheptanoic acid
  • Bz-DAVD-phenylpropyl ketone
  • 12-Lipoxygenase (12-LOX)
  • 15-Lipoxygenase-2 (15-LOX-2)
  • Arachidonate 15-lipoxygenase
  • Arachidonate 5-lipoxygenase
5 IC50
  • 6,7‐dihydroxy‐3‐(4‐nitrophenyl)‐4H‐chromen‐4‐one
  • 6,7-Dihydroxy-4′-nitroisoflavone (1b)
  • IR-6
  • Acetylcholinesterase
  • Bile salt export pump
  • Cholinesterases
  • Neuronal acetylcholine receptor subunit alpha-4
1 Ki 9 IC50
  • 1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-methylcarbamate
  • CHEMBL11773
  • Eserine
  • Physostigmine
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 2
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 3
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 4
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 5
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 6
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 7
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 8
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 9
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 10
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 12
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 13
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 14
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 15
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 16
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 17
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 18
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 19
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 20
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 21
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 22
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 23
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 24
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 25
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 26
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 27
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 28
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 29
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 30
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 31
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 32
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 33
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 34
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 35
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
4 IC50
  • US8592415, 36
  • Acetylcholinesterase
  • Butyrylcholinesterase (BChE)
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
4 IC50
  • 3-amino-2,3-dihydro-1H-inden-5-yl N,N-dimethylcarbamate
  • Aminoindan deriv. 7a
  • Acetylcholinesterase
  • Butyrylcholinesterase (BChE)
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
4 IC50
  • (3R)-3-amino-2,3-dihydro-1H-inden-5-yl N-ethyl-N-methylcarbamate hydrochloride
  • Aminoindan deriv. 7b
  • Aminoindan deriv. 7b-(R).HCl
  • Acetylcholinesterase
  • Butyrylcholinesterase (BChE)
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
4 IC50
  • 3-(methylamino)-2,3-dihydro-1H-inden-5-yl N,N-dimethylcarbamate
  • Aminoindan deriv. 8a
  • Acetylcholinesterase
  • Butyrylcholinesterase (BChE)
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
4 IC50
  • 1-amino-2,3-dihydro-1H-inden-4-yl N,N-dimethylcarbamate
  • Aminoindan deriv. 13a
  • Acetylcholinesterase
  • Butyrylcholinesterase (BChE)
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
4 IC50
  • 1-amino-2,3-dihydro-1H-inden-4-yl N-ethyl-N-methylcarbamate
  • Aminoindan deriv. 13b
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
5 IC50
  • US8592410, 13
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
5 IC50
  • US8592410, 14
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
5 IC50
  • US8592410, 16
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
5 IC50
  • US8592410, 17
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
5 IC50
  • US8592410, 19
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
5 IC50
  • US8592410, 20
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
10 IC50
  • US8575157, 194
  • US8592410, Comparator 6
  • US8598163, 64
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
10 IC50
  • US8575157, 199
  • US8592410, Comparator 11
  • US8598163, 69
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
12 IC50
  • US8575157, 200
  • US8592410, Comparator 12
  • US8598163, 70
  • 11-beta-hydroxysteroid dehydrogenase 1
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 3A
10 IC50
  • US8575157, 202
  • US8592410, Comparator 14
  • US8598163, 72
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