Compile Data Set for Download or QSAR
Report error Found 279 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2 [831-1132]'
TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50503287BDBM50503287(ABT-494 | Rinvoq | Upadacitinib | US10961228, Exam...)
Affinity DataIC50: 64nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488640BDBM488640(US10961228, Example Tofacitinib | US11414413, Exam...)
Affinity DataIC50: 130nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488735BDBM488735(US10961228, Example 27 | (S)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 162nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 489172BDBM489172(US10961228, Example 55 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 293nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264233BDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)
Affinity DataIC50: 322nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264233BDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)
Affinity DataIC50: 322nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264233BDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)
Affinity DataIC50: 322nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488719BDBM488719(US10961228, Example 26 | (R)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 456nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 489047BDBM489047(US10961228, Example 42 | (R)-N-(3-(2-((2-fluoro- 3...)
Affinity DataIC50: 604nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 489168BDBM489168(US10961228, Example 51 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 612nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 489174BDBM489174(US10961228, Example 57 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 709nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 489073BDBM489073(US10961228, Example 45 | (R)-N-(3-(5-fluoro-2- ((2...)
Affinity DataIC50: 718nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488689BDBM488689(US10961228, Example 16 | (R)-N-(3-(2-((2-fluoro- 3...)
Affinity DataIC50: 725nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264225BDBM264225((2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)
Affinity DataIC50: 790nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264225BDBM264225((2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)
Affinity DataIC50: 790nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264225BDBM264225((2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)
Affinity DataIC50: 790nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 489180BDBM489180(US10961228, Example 64 | (R)-3-(benzyloxy)-N- 3-(2...)
Affinity DataIC50: 910nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488809BDBM488809(US10961228, Example 37 | (R)-N-(3-(2-((2-fluoro-3-...)
Affinity DataIC50: 968nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488761BDBM488761(US10961228, Example 30 | (S)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 1.16E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488758BDBM488758(US10961228, Example 29 | (R)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 1.20E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488779BDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 1.22E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264240BDBM264240((2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)
Affinity DataIC50: 1.53E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264240BDBM264240((2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)
Affinity DataIC50: 1.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264240BDBM264240((2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)
Affinity DataIC50: 1.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264217BDBM264217((2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyr...)
Affinity DataIC50: 1.58E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264217BDBM264217((2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyr...)
Affinity DataIC50: 1.58E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488661BDBM488661(US10961228, Example 1 | (R)-N-(3-(2-((2-fluoro- 3-...)
Affinity DataIC50: 1.58E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264217BDBM264217((2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyr...)
Affinity DataIC50: 1.58E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488667BDBM488667(US10961228, Example 4 | (R)-N-(3-(2-(3- cyclopropy...)
Affinity DataIC50: 1.60E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264216BDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)
Affinity DataIC50: 1.76E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264216BDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)
Affinity DataIC50: 1.76E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264216BDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)
Affinity DataIC50: 1.76E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264229BDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50: 1.77E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264229BDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50: 1.77E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264229BDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50: 1.77E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488763BDBM488763(US10961228, Example 31 | (R)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 1.79E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488777BDBM488777(US10961228, Example 33 | (R)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 1.93E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264224BDBM264224((2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-y...)
Affinity DataIC50: 1.95E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264224BDBM264224((2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-y...)
Affinity DataIC50: 1.95E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264224BDBM264224((2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-y...)
Affinity DataIC50: 1.95E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264244BDBM264244((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Affinity DataIC50: 2.04E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 313401BDBM313401((2R)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)...)
Affinity DataIC50: 2.04E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 313401BDBM313401((2R)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)...)
Affinity DataIC50: 2.04E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 489170BDBM489170(US10961228, Example 53 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 2.08E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 704697BDBM704697(US20240376080, Compound 2S)
Affinity DataIC50: 2.19E+3nMAssay Description:1. Experimental Method1.1. Pseudokinase (JH2) Experimental Operation was as Follows:1.1.1. Dissolve the compound with DMSO to a storage concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488685BDBM488685(US10961228, Example 14 | (R)-N-(3-(2-((2-fluoro- 3...)
Affinity DataIC50: 2.43E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264194BDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)
Affinity DataIC50: 2.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264194BDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)
Affinity DataIC50: 2.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 264194BDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)
Affinity DataIC50: 2.53E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 488710BDBM488710(US10961228, Example 22 | (R)-N-(3-(2-((2-fluoro- 3...)
Affinity DataIC50: 2.56E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

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