226 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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13
Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents.
Svkm'S Dr. Bhanuben Nanavati College of Pharmacy
25
Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells.
Universidade De Lisboa
32
Phenyltetrazolyl-phenylamides: Substituent impact on modulation capability and selectivity toward the efflux protein ABCG2 and investigation of interaction with the transporter.
Rheinische Friedrich-Wilhelms-Universit£T Bonn
3
Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.
Chang Gung Memorial Hospital
9
Halogenated naphthochalcones and structurally related naphthopyrazolines with antitumor activity.
University Bayreuth
3
Synthesis and bioevaluation of novel benzodipyranone derivatives as P-glycoprotein inhibitors for multidrug resistance reversal agents.
China Medical University
14
Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport.
Kyoto University
26
The combination of quinazoline and chalcone moieties leads to novel potent heterodimeric modulators of breast cancer resistance protein (BCRP/ABCG2).
University of Bonn
30
Optimization by Molecular Fine Tuning of Dihydro-ß-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.
Instituto Universitario De Bio-Org£Nica&Quot;Antonio Gonz£Lez&Quot
32
Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.
University of Regensburg
38
The interaction of 4-thiazolidinone derivatives containing indolin-2-one moiety with P-glycoprotein studied using K562 cell lines.
The First Affiliated Hospital of Dalian Medical University
10
Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors.
Ocean University of China
2
Discovery of substituted 1,4-dihydroquinolines as novel promising class of P-glycoprotein inhibitors: First structure-activity relationships and bioanalytical studies.
Martin-Luther-University Halle-Wittenberg
55
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
The Hong Kong Polytechnic University
4
Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-ß-agarofuran Sesquiterpenes from Celastrus vulcanicola.
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Iubo-Ag)
1
In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.
Glaxosmithkline
19
HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).
University of Bonn
23
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.
University of Bari Aldo Moro
2
Investigating the binding interactions of the anti-Alzheimer's drug donepezil with CYP3A4 and P-glycoprotein.
University of Waterloo
21
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity froms2 receptor affinity in mixed P-gp/s2 receptor agents.
University of Bari Aldo Moro
20
SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.
University of Bari Aldo Moro
14
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Novartis Institutes For Biomedical Research
2
4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells.
Ocean University of China
8
Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.
St. John'S University
21
Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein.
Medical University Vienna
16
SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.
University of Pisa
34
Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).
University of Bonn
8
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging ofs2 receptors.
University of Bari Aldo Moro
5
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.
Duquesne University
10
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.
University of Bari Aldo Moro
14
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.
University of Bari Aldo Moro
17
Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators.
University of Regensburg
41
Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain.
Chosun University
1
Intrinsic and acquired forms of resistance against the anticancer ruthenium compound KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A).
Institute of Cancer Research
2
Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein.
Kobe University
6
Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4.
Kanazawa University
4
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.
Kanazawa University
1
Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein.
Kyoto University Hospital
5
Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay.
Strasbourg 1 University
9
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
The University of Kansas
3
HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein.
Schering-Plough Research Institute
6
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.
Schering-Plough Research Institute
1
The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.
Schering-Plough Research Institute
1
Cholesterol interaction with the daunorubicin binding site of P-glycoprotein.
Schering-Plough Research Institute
1
P-glycoprotein interactions of nefazodone and trazodone in cell culture.
Tufts University School of Medicine
1
Methadone inhibits rhodamine123 transport in Caco-2 cells.
Tufts University School of Medicine
3
Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein.
Schering-Plough Research Institute
27
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Schering-Plough Research Institute
2
Interaction of common azole antifungals with P glycoprotein.
Schering-Plough Research Institute
10
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.
Vanderbilt University School of Medicine
1
Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein.
Tufts University School of Medicine
1
Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.
Vanderbilt University School of Medicine
4
Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein.
Vanderbilt University
3
Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein.
Institute of Clinical Pharmacology
2
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
1
Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104P.
University of Paris Nord
12
Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.
Chosun University
8
Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.
Pfizer
5
Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity.
Korea Research Institute of Chemical Technology
1
Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine.
Washington University
2
Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.
Eli Lilly
12
New functional assay of P-glycoprotein activity using Hoechst 33342.
University of Bonn
3
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold.
University of Bologna
2
Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.
Yale University
4
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.
Georgetown University School of Medicine
26
Synthesis and evaluation of hapalosin and analogs as MDR-reversing agents.
Eisai Research Institute
11
Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1).
The State University of New York
12
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Uppsala University
1
Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.
Merck Research Laboratories
19
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Eli Lilly
2
Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein.
Eli Lilly
1
Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
3
PSC833, cyclosporin A, and dexniguldipine effects on cellular calcein retention and inhibition of the multidrug resistance pump in human leukemic lymphoblasts.
University of Tennessee Medical Center
1
Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system.
F. Hoffmann-La Roche
3
From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity.
TBA
10
Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro.
Gilead Sciences
16
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
University of Regensburg
30
Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
University of Bonn
16
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
University of Bari Aldo Moro
27
Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.
Universita Degli Studi Di Bari
159
Self-organizing maps for identification of new inhibitors of P-glycoprotein.
University of Vienna
22
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.
University of Bologna
30
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
F. Hoffmann-La Roche
22
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Bulgarian Academy of Sciences
59
Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter.
Strasbourg 1 University
28
Aureobasidins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC-transporter.
Strasbourg 1 University
24
Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.
University of Vienna
10
The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.
University of Lyon 1
47
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.
University of Bari Aldo Moro
8
Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-ß-agarofuran sesquiterpenes.
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Iubo-Ag)
14
Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).
Universidad Nacional De Colombia
4
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.
University of Perugia
1
Interaction potential of etravirine with drug transporters assessed in vitro.
University Hospital Heidelberg
30
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
University of Bonn
6
Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.
Umr 5086 Cnrs
36
Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.
Universita Degli Studi Di Torino
16
Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone.
Philipps-Universit£T Marburg
20
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide"switch" for ATPase activity.
The State University of New York
38
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.
Universita Degli Studi Di Bari
5
Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.
Instituto Universitario De Bio-OrgáNica Antonio GonzáLez
4
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
Università
13
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948.
Pfizer Inc.
10
Functional and structural polypharmacology of indazole-based privileged ligands to tackle the undruggability of membrane transporters.
University of Lubeck and University Medical Center Schleswig-Holstein
4
Design, synthesis and biological evaluation of biaryl amide derivatives as modulators of multi-drug resistance.
Fudan University
23
Discovery of novel third generation P-glycoprotein inhibitors bearing an azo moiety with MDR-reversing effect.
Xuzhou Medical University
8
Advances in synthesis of novel annulated azecines and their unique pharmacological properties.
Peoples' Friendship University of Russia (RUDN University)
24
Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers.
University of Florence
27
Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
Jacobio Pharmaceuticals
13
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
Pfizer
3
Progress on synthesis and structure-activity relationships of lamellarins over the past decade.
Zhejiang Chinese Medical University
32
Design, synthesis, molecular modeling, in vitro and in vivo biological evaluation of potent anthranilamide derivatives as dual P-glycoprotein and CYP3A4 inhibitors.
University of Nebraska Medical Center
1
Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
University of Southern Denmark
72
Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.
Instituto Universitario De Bio-Organica Antonio Gonzalez
2
Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases.
Idorsia Pharmaceuticals Ltd.
10
The mechanisms of multidrug resistance of breast cancer and research progress on related reversal agents.
University of South China
74
Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity.
Zhejiang University
13
Consensus screening for a challenging target: the quest for P-glycoprotein inhibitors.
The Scripps Research Institute
73
Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
Leibniz-Fmp
8
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).
Université
6
Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.
National Institute of Pharmaceutical Education and Research-Hyderabad
12
Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid
The Hong Kong Polytechnic University
19
Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1).
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management
43
9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein.
University of Bonn
1
Discovery of a novel highly potent and low-toxic jatrophane derivative enhancing the P-glycoprotein-mediated doxorubicin sensitivity of MCF-7/ADR cells.
Xinjiang Technical Institute of Physics & Chemistry
4
Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors.
National Institute of Pharmaceutical Education and Research-Hyderabad
4
Pyrimidine: A promising scaffold for optimization to develop the inhibitors of ABC transporters.
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)
10
Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition.
Università
5
Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells.
Martin-Luther-University Halle-Wittenberg
24
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
China Pharmaceutical University
2
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.
Columbia University College of Physicians and Surgeons
2
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.
Columbia University College of Physicians and Surgeons
10
Glenthenamines A-F: Enamine Pyranonaphthoquinones from the Australian Pasture Plant Derived
The University of Queensland
147
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
Central South University
26
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1
Bristol Myers Squibb
56
Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore.
The University of Queensland
23
Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
Athenex
3
Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.
Hong Kong Polytechnic University
4
Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors.
Zhengzhou University
47
Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.
Xenova
36
Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated protein in multidrug resistance.
Xenova
52
Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).
Hong Kong Polytechnic University
21
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.
Athenex
20
C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors.
University of Bonn
4
Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity.
Yantai University
21
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Zhejiang University
21
Dihydro-β-agarofuran-Type Sesquiterpenoids from the Seeds of
Chinese Academy of Sciences
27
Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance.
China Pharmaceutical University
5
Synthesis and biological evaluation of thiophenylbenzofuran derivatives as potential P-glycoprotein inhibitors.
China Medical University
22
Water-soluble inhibitors of ABCG2 (BCRP) - A fragment-based and computational approach.
University of Regensburg
25
Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-Spectrum ABCB1, ABCC1, and ABCG2 Antagonists.
Rheinische Friedrich-Wilhelms-University Bonn
19
Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site.
Rheinische Friedrich-Wilhelms-University of Bonn
21
Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).
Eli Lilly
18
Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP).
University of Regensburg
30
Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.
Xenova
55
Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5-
Zhengzhou University
4
Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs.
Taipei Chang Gung Memorial Hospital
8
B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance.
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063
20
Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue.
Peking Union Medical College
9
Chrysosporazines F-M: P-Glycoprotein Inhibitory Phenylpropanoid Piperazines from an Australian Marine Fish Derived Fungus,
The University of Queensland
41
Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2).
University of Bonn
14
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein.
University of Turin
31
Synthesis and Biological Evaluation of 4-Anilino-quinazolines and -quinolines as Inhibitors of Breast Cancer Resistance Protein (ABCG2).
University of Bonn
42
Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2.
Rheinische Friedrich-Wilhelms-University of Bonn
18
Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells.
University of Turin
5
Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity.
Purdue University
11
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.
University of Florence
6
Tetrazole hybrids with potential anticancer activity.
Henan University of Chinese Medicine
2
Discovery and synthesis of 3- and 21-substituted fusidic acid derivatives as reversal agents of P-glycoprotein-mediated multidrug resistance.
Yantai University
25
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.
University of Florence
34
Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance.
East China University of Science and Technology
11
Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches.
TBA
6
Natural products as multidrug resistance modulators in cancer.
Central University of Punjab
16
Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach.
Rheinische Friedrich-Wilhelms-University of Bonn
38
Synthesis and biological evaluation of quinazoline derivatives - A SAR study of novel inhibitors of ABCG2.
University of Bonn
24
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.
University of Bari Aldo Moro
5
Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents.
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)
3
Design, synthesis, and discovery of ocotillol-type amide derivatives as orally available modulators of P-glycoprotein-mediated multidrug resistance.
Universities of Shandong
93
Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.
Hong Kong Polytechnic University
2
Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance.
Jinan University
4
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters.
University of Florence
1
Selenorhodamine photosensitizers for photodynamic therapy of P-glycoprotein-expressing cancer cells.
The State University of New York
6
Homodimers of the Antiviral Abacavir as Modulators of P-glycoprotein Transport in Cell Culture: Probing Tether Length.
Purdue University
4
Structure-activity relationship study of permethyl ningalin B analogues as P-glycoprotein chemosensitizers.
Ocean University of China
4
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.
Duquesne University
3
20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.
Chinese Academy of Sciences
30
New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).
University of Florence
2
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.
The Hong Kong Polytechnic University
2
Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1).
The State University of New York
18
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
St. Jude Children'S Research Hospital
10
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.
Kyoto Pharmaceutical University
6
Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter.
The University of Kansas
7
A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.
The University of Kansas
1
Reversal of P-glycoprotein-associated multidrug resistance by ivermectin.
Institute of Parasitology of Mcgill University
2
Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.
University of Tokyo
1
P-glycoprotein inhibition by the multidrug resistance-reversing agent MS-209 enhances bioavailability and antitumor efficacy of orally administered paclitaxel.
Nihon Schering K.K.
1
Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate.
Avmax
1
Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein.
University of North Carolina
1
Interaction of cyclosporin derivatives with the ATPase activity of human P-glycoprotein.
Novartis Takarazuka Research Institute
1
Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A.
Tufts University School of Medicine
31
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
University of Vienna
8
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux.
Purdue University
22
Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity.
University of Bonn
43
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators.
University of Bonn
1
Discovery of traditional Chinese medicine monomers and their synthetic intermediates, analogs or derivatives for battling P-gp-mediated multi-drug resistance.
Anhui University of Chinese Medicine
9
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ
University of Bari Aldo Moro
35
Structure activity relationships, multidrug resistance reversal and selectivity of heteroarylphenyl ABCG2 inhibitors.
Rheinische Friedrich-Wilhelms-Universit£T Bonn
3
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
Csir - Indian Institute of Integrative Medicine
1
Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).
Zhengzhou University
52
Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2).
University of Bonn
21
Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors.
China Pharmaceutical University
2
Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.
China Pharmaceutical University
3
Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and ABCG2 based on the antiviral azidothymidine.
Purdue University
4
Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.
St. John'S University
11
Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.
University of Montana
47
4-Anilino-2-pyridylquinazolines and -pyrimidines as Highly Potent and Nontoxic Inhibitors of Breast Cancer Resistance Protein (ABCG2).
University of Bonn
128
SPIROCYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION
Genentech
21
3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose
Sanwa Kagaku Kenkyusho
3
Substrate specificity of Sphingobium chlorophenolicum 2,6-dichlorohydroquinone 1,2-dioxygenase.
Whitman College